///2019 Abstract Details
2019 Abstract Details2019-07-13T07:45:15-05:00

Short-term effect of acupuncture for adenomyosis: a systematic review and meta-analysis

Abstract Number: F3C-478
Abstract Type: Original Research

Sue Yuan PhD.1 ; Qi Li Medical student2; Sue Yuan Ph D3

Background: Adenomyosis is a common disease in women during reproductive age, which is associated with uterine enlargement, pelvic pain, excessive vaginal bleeding, and may decrease their quality of life. Hysterectomy is the standard treatment for adenomyosis, but not all patients of reproductive age can accept it. Acupuncture is increasingly popular as a complementary therapy in the treatment of adenomyosis. The aim of our systematic review was to evaluate the effect of acupuncture for adenomyosis.

Method: Ten electronic databases were searched for relevant articles published before January 2019. We searched Pubmed、Cochrane、Embass、Proquest、Web of science、Medline、Scopus、China National Knowledge Infrastructure (CNKI), VIP Information and the WanFang database. This study included randomized controlled trials (RCTs) of women with adenomyosis. The intervention was acupuncture combined or not combined with medicine. The comparison of acupuncture was medicine. The primary outcome was clinical efficacy、uterine size and dysmenorrhea severity and dysmenorrhea symptom, the secondary outcome was CA-125 level and adverse effect. The methodological quality was evaluated using the Cochrane risk-of-bias criteria. The results were analyzed by Review Manager 5.3 and expressed as Standardized mean differences (SMD) or mean differences (MD) with 95% confidence interval (CI).

Result: Eight RCTs (602 individual) were included. The results showed that acupuncture was more effective than medicine in clinical efficacy (Odds Ratio, OR=0.27, 95% CI= [0.17,0.45]), less severity in dysmenorrhea severity score (Mean Difference, MD=-2.06, 95% CI= [-2.70, -1.42]), and much smaller in uterine size (SMD=-0.38, 95% CI= [-0.69, -0.07]). The CA125 level (SMD=-0.72, 95% CI= [-1.07, -0.38]) was significant decreased compared to medicine treatment, VAS (SMD=-2.43, 95% CI= [-4.37, -0.49]) improved a lot. After 3 cycles treatment by acupuncture, the menstrual blood loss (SMD=-2.68, 95% CI= [-4.33, -1.04]) and the adverse effect Night sweats (OR=0.16, 95% CI= [0.03,0.94]) was reducing. The dysmenorrhea symptom (SMD=-0.69, 95% CI= [-1.50,0.12]) seems no significant change after 3cycles treatment by acupuncture.

Conclusion: After 3-cycles treatment by acupuncture, it seems that symptoms of adenomyosis improved compared to medicine with increased clinical efficacy, less pain severity, and smaller uterine size and fewer side effects. However, more high-quality randomized controlled trials and data is needed to support it.

SOAP 2019