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Genetic Associations of Perinatal Pain and Depression
Abstract Number: F310-46
Abstract Type: Original Research
Introduction. Underlying biological factors, such as genetic influences, may significantly influence perinatal pain, postpartum depression, or both. We investigated the role of 59 single nucleotide polymorphisms (SNP) on 20 quantitative traits measured in perinatal women.
Methods. We prospectively enrolled and genotyped 184 pregnant women for 59 SNPs that had known prior associations with either pain or depression in non-pregnant populations. Prenatal biological (saliva) samples were collected between 28-37 weeks gestation. Phenotypic data were prospectively gathered during prenatal, labor and delivery, and postpartum (six weeks and three months) periods, capturing labor pain, Edinburgh Postnatal Depression Score, and Brief Pain Inventories. Following quality control, genotypes were used as predictors and phenotypes as dependent variables in multiple linear regression analyses to detect associations. Three statistical models were tested: additive allele effects, deviation from dominant allele effects, and the joint test of both. Multiple comparisons were addressed using the Benjamini and Hochberg false discovery rate (FDR).
Results. Associations were detected for rs4633 (a synonymous SNP in COMT) with “pain right now” scores at six-weeks postpartum from the Brief Pain Inventory, and for rs1135349 (a SNP within a small non-coding RNA that has many prior associations for depression) with the maximum pain unpleasantness score experienced during labor (a measure of the emotional valence of labor pain). Sensory dimensions of labor pain (i.e., pain intensity) and postpartum depression scores were not significantly associated with the genotyped SNPs.
Conclusions. SNPs in a non-coding RNA transcript associated with depression and in COMT, are linked to the emotional valence of labor pain and to pain at six weeks postpartum, respectively. Identifying genomic components of these perinatal complex disorders may produce insights into relevant pathways or novel treatment options.