Join now to get access to this content and more.
Become a SOAP member and have access to our benefits.
- For Review: SOAP Consensus Statement on Neuraxial Procedures in Thrombocytopenic Parturients
- Sample Centers of Excellence Applications
- ASA Corner
- SOAP Policy and Procedure Manual (P&P Manual)
- SOAP Expert Opinions
- SOAP's Learning Modules
- 2019 Annual Meeting Lecture Videos
- December 2018 - SOAP Unofficial Guide to ASA Committees Webinar
- Submit a Position
- View Job Postings
- Previous Meeting Archives
- Previous Meeting Abstract Search
- CMS Guidelines
- Member Benefits
- Newsletter Clinical Articles
- ACOG Documents
- Search our Patient Safety Archive
- Ask SOAP a Question
- Global Health Opportunities
- And more…
The Effective Effect-Site Propofol Concentration for Induction and Intubation for Schnider model in parturients
Abstract Number: T-35
Abstract Type: Original Research
Background To determine the target propofol Ce needed to provide adequate hypnosis for induction and tracheal intubation for Schnider model using total body weight (TBW) in parturients. Objectives 36 patients were allocated to 6 groups of predefined propofol target Ce for induction. Propofol was administered by the TCI device to achieve the predetermined target propofol Ce. The dose-response relation for propofol Ce was determined using probit analysis. An effective Ce, or success, was defined as the Ce that provided adequate hypnosis (BIS<60) within 45 seconds after reaching the predetermined Ce and until the Ce was reset to 2.5 µg.mL-1 after intubation.
Results For the Schnider model, the calculated ECe50 was 5.06 µg.mL-1 (95% CI: 4.68, 5.42 µg.mL-1), and the ECe95 was 5.86 µg.mL-1 (95% CI:5.46 , 7.69 µg.mL-1)
Conclusion In conclusion, given the inaccuracies of the PK models of propofol, particularly when used in parturients during induction, specific propofol Ce values determined with Schnider model must be used during this stage of anesthesia when using TBW.
[Key words] propofol；parturients；intubation；induction