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Association between ionized Mg, total Mg, and perinatal outcomes in infants with maternal preclampsia
Abstract Number: S-77
Abstract Type: Original Research
OBJECTIVE: Magnesium sulfate(MgSO4) is a commonly used drug for women with preeclampsia because of its effect that it reduces progression to eclampsia. This study was aimed to evaluate the association between total magnesium (tMg) and ionized Mg (iMg) and gestational age in preterm babies and secondly to access the association between hypermagnesemia and adverse outcomes.
METHODS: A prospective study was performed in inborn preterm infants who were admitted to neonatal intensive care units. TMg, iMg, pH, total calcium Ca (tCa), ionized Ca (iCa) were collected immediately after delivery or within 3 hours of age. Incidence of respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH) were compared between hypermagnesemia, defined as more than 2.9 mg/ dL, and normal group.
RESULTS: One hundred twenty nine neonates were eligible for this study. IMg was significantly correlated with tMg (r = 0.367, p < 0.001). However, there were no correlation between iMg and gestational age, tCa, pH, iCa, Apgar score at 1 min, and Apgar score at 5 min. Among adverse outcomes, only the incidence of IVH was higher in hypermagnesemia than normal group (23.8% vs 7.5%, p = 0.04).
CONCLUSIONS: In preterm babies less than 37 weeks of age, the level of iMg was similar regardless of gestational age and preterm babies with high magnesium level without additional magnesium exposure should be screened for IVH.