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///2015 Abstract Details
2015 Abstract Details2019-08-02T16:54:43-05:00

Is Maternal Temperature Rise During Labor Analgesia a Physiological Process Due to Decreased Pulmonary Ventilation?

Abstract Number: GM-05
Abstract Type: Original Research

Lynn O Choi MD1 ; Lynn O Choi MD2; Jordan Brayanov PhD3; Arvind Palanisamy MD, MBBS4; Lawrence C Tsen MD5; Bhavani S Kodali MD6

Background: Maternal fever occurs in approximately 15-30% of laboring women after epidural analgesia. Proposed mechanisms include inflammation and thermoregulatory imbalance during labor. Though inflammation is reasonably well characterized, not much is known about altered heat balance during labor. Here, we propose a novel mechanism to potentially explain the gradual rise in temperature after epidural analgesia. Specifically, we hypothesize that a decrease in minute ventilation after effective epidural analgesia causes a decrease in heat dissipation, and therefore, promotes heat retention over time.

Methods: To investigate this hypothesis,18 parturients (age: 33.7 ± 3.4 yrs, BMI: 29.4 ± 2.8 kg/m2) who requested labor epidural analgesia were enrolled. Continuous respiratory minute ventilation (RMV) traces were recorded using an impedance-based system (ExSpiron, Respiratory Motion, Inc.) before, during, and after administration of labor epidural analgesia. A turbine spirometer (nSpire Health, Inc.) was used to calibrate the RMV system prior to epidural placement. Baseline minute ventilation (MV), tidal volume (TV) and respiratory rate (RR) were determined 20-min before epidural placement and subsequent changes during labor were recorded. Oral temperatures were obtained every 90 minutes. Unpaired 2-sided t-tests were used to evaluate changes in post-epidural respiratory measurements compared to baseline.

Results: Following the administration of the epidural analgesia, the average MV decreased by 28.1%±8.4% within 2 hours and reached a nadir of 32.6%±6.1% below baseline approximately 5 hours after epidural catheter placement (p<0.05 for both comparisons, Fig 1A&B). Meanwhile, average body temperature underwent a linear increase by 0.13±0.13 °F and 0.28±0.1°F (Fig 1C&D) at 2 and 5 hours, respectively (p>0.05 for both comparisons). The decrease in MV was driven primarily by a decrease in TV rather than RR.

Conclusions: Our preliminary results confirm part of our hypothesis that effective epidural analgesia would significantly decrease respiratory minute ventilation. Though there was a trend towards increased body temperature during labor analgesia, our current sample size does not allow meaningful interpretation of the data. Further enrollment will allow us to characterize changes in ventilation in those patients who do and do not develop fever.


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