A retrospective analysis of effect of anesthesia on outcome of in vitro fertilization
Abstract Number: F-69
Abstract Type: Original Research
Pain relief for transvaginal ultrasound guided oocyte aspiration for in vitro fertilization is provided by various anesthetic techniques like general anesthesia, sedation or locoregional anesthesia. There are concerns that different anesthetic drugs used may have potential adverse effects on outcome of pregnancy after this procedure. Present study was conducted to know the outcome of pregnancy after in vitro fertilization using different anesthetic techniques.
A retrospective analysis of data collected from medical records of patients who underwent transvaginal ultrasound guided oocyte aspiration from a tertiary care teaching institute in India from September 2007 to March 2013 was done. Data collected were demographic variables, details of the anesthetic technique, pregnancy outcome variables including number of oocytes retrieved, fertilization rate, embryo quality grading, biochemical and clinical pregnancy rate, live birth rate and other outcomes like miscarriage, ectopic pregnancy.
After excluding 17 patients who were lost to follow up, data from 989 patients were analysed. Out of this 419 patients(group 1) received general anesthesia and 570 patients(group 2) received sedation. Age, BMI, duration of infertility were comparable between the two groups.There were no difference between number of oocytes retrieved per cycle, fertilization rate, embryo quality, clinical pregnancy rate or miscarriage rate between the two groups. Biochemical pregnancy rate (25.54% vs 19.82%,P=0.03) and live birth rate (18.61% vs 13.85%,P=0.04) were significantly higher for group 1 compared to group 2.
Pregnancy outcome was better in patients who received general anesthesia compared to patients who received sedation. More prospective studies are needed to confirm this finding.