///2010 Abstract Details
2010 Abstract Details2018-05-01T17:52:49+00:00

Obesity is risk factor for developing preeclampsia in pregnant women

Abstract Number: 27
Abstract Type: Original Research

Efim M Shifman MD1 ; Galina P Tikhova No2; Svetlana E Floka No3

Introduction: Preeclampsia is a common, yet incompletely understood, complication of pregnancy. It is supposed that severe obesity registered in early period of pregnancy increases risk of preeclampsia/eclampsia. This study was carried out in order to prove or reject this assumption using statistical methods.

Methods: Multicenter retrospective observational study includes 2278 case records where nutritional status (NS) was registered in early pregnancy as well as pregnancy or labour complications. All case records were stratified by severe obesity (yes/no) into two groups (group A - yes, group B - no) and the number of preeclampsia/eclampsia cases was calculated in each group. This data set was statistically analyzed.

Results: The results are presented in the Table 1.

Preeclampsia rate in group with obesity was 50.0%3.5% (95%CI: 43.3% - 57.1%), in group with normal NS - 18.5%0.9% (95%CI: 16.7% - 20.3%), p<0.001. Odds value in group A was 1.01, in group B - 0.23. Odds ratio was 4.4 and relative risk was 2.7 (95%CI: 2.3 - 3.2). Risk Relative Increasing was 171.3% and Attributive Risk was 31.7% 1,4% (95%CI: 29.0% - 34.4%). NNT equaled to 3.15 (95%CI: 2.9 - 3.5).

Discussion: The difference in preeclampsia rate between two groups is statistically significant.

In group with severe obesity the rate of preeclamsia is 2.7 times higher than in group with normal NS. For each obese parturient risk of preeclampsia is 31.7% (in average) greater than for women with normal NS and odds of preeclampsia for obese patients is 1:1 while for women with normal NS - 1:4. The NNT parameter indicates that for any three women with severe obesity at least one will develop preeclamsia.

Conclusion: Severe obesity in pregnant women is statistically and clinically significant risk factor for developing preeclampsia/eclampsia.

SOAP 2010