///2010 Abstract Details
2010 Abstract Details2018-05-01T17:52:49+00:00

THE COMPARISON OF TWO DIFFERENT PATIENT-CONTROLLED EPIDURAL ANALGESIA FORMULAE FOR POST CESAREAN SECTION ANALGESIA: LEVOBUPIVACAINE WITH OR WITHOUT FENTANYL

Abstract Number: 20
Abstract Type: Original Research

Shin-Yan Chen MD1 ; Li-Kuei Chen MD, Ph.D2; Shou-Zen Fan MD, Ph.D3

Purpose

This prospective, double-blind, randomized study is designed to evaluate the quality of analgesic effect and the incidence of side effects of two different patient-controlled epidural analgesic (PCEA) formulae by using pure Levobupivacaine or Levobupivacaine plus Fentanyl for patients after cesarean section (C/S).

METHODS

ASA class I/II, full-term pregnant women who received elective C/S and submitted permission for PCEA were enrolled in the study. All recruited patients were randomly assigned to 2 groups: Group A with 0.6 mg/ml Levobupivacaine + 2 ug/ml Fentanyl, and Group B with pure 1 mg/ml Levobupivacaine. The setting for PCEA in all patients is the same as 2 ml for bolus, 3 ml/hour for continuous infusion, 20 min for lock out interval and 40 ml for 4-hour limit. The primary outcome in this study was the dynamic and resting pain scores (visual analog scale) on the first post operative day. Secondary outcomes were adverse events, volume of regimen administered, and patients satisfaction.

RESULTS

64 patients were included in the study (28 in group A and 36 in group B). Total drug consumptions have no significant difference (P=0.28). Average resting pain score has no difference in two groups (2.39 vs 2.38, P=0.96). Average dynamic pain score has no difference in two groups (4.01 vs 4.13, P=0.77). In adverse reactions, nausea or vomiting was 25.0% vs 11.11%; dizziness was 46.43% vs 13.89%; pruritus was 29.63% vs 5.56%; lower limb numbness was 39.29% vs 72.22%; sleepiness was 21.43% vs 13.89%; and urinary retention was 10.71% vs 11.11%. Patients satisfaction was good in both groups (p=0.62)

CONCLUSIONS

In our study, there was no significant difference in reducing resting and dynamic pain score when using pure levobupivacaine or levobupivacaine plus fentanyl. Patients in group A were more significantly bothered by nausea or vomiting, dizziness pruritus and sleepiness; patients in group B by lower limb numbness. However, the overall satisfaction was good for both group patients.

SOAP 2010