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///2009 Abstract Details
2009 Abstract Details2019-08-03T15:55:31-05:00

Hemodynamic effects of oxytocin 5 units in preeclamptic patients compared to healthy pregnant women

Abstract Number: 7
Abstract Type: Original Research

Eldrid Langester M.D1 ; Leiv Arne Rosseland M.D., PhD2; Audun Stubhaug M.D., PhD3

Background: The aim of the study was to quantify the hemodynamic changes after 5 units oxytocin in women with severe preeclampsia, and compare these findings with changes in healthy parturients.

Methods: Eighteen women with severe preeclampsia were monitored during C-section with continuous invasive blood pressure and using the LiDCOplus for CO-monitoring. The women were given 5 units oxytocin after delivery of the baby. The hemodynamic effects of oxytocin in these preeclamptic women were compared to findings in 80 healthy women from a study performed simultaneously in otherwise healthy women undergoing caesarean section 1.

Results: After 5 units oxytocin, compared with healthy pregnant women, women with severe preeclampsia had clinically and statistically significant less changes in cardiac output (32% vs 85 %), in stroke volume (6% vs 38%), and in heart rate (22% vs 42%), p<0.0001. Systemic vascular resistance decreased 52% in preeclamptic women compared to 62% in healthy women, p<.0001. There was no difference in the effect on systolic blood pressure between healthy and preeclamptic women (see Figure 1).

Discussion: These findings could suggest that preeclamptic women are less able to compensate with an increase in cardiac output after stress as healthy pregnant women, or that the vasodilatory effect of oxytocin on the endothelium is less pronounced in preeclamptic women. These findings need further investigation.

Reference List

1. Langesaeter E, Rosseland LA, Stubhaug A: Continuous Invasive Blood Pressure and Cardiac Output Monitoring during Cesarean Delivery: A Randomized, Double-blind Comparison of Low-dose versus High-dose Spinal Anesthesia with Intravenous Phenylephrine or Placebo Infusion. Anesthesiology 2008; 109: 856-63

SOAP 2009