///2009 Abstract Details
2009 Abstract Details2019-08-03T15:55:31-06:00

Sleep Apnea Symptoms During Pregnancy and Infant Birth Weight

Abstract Number: 24
Abstract Type: Original Research

Louise M O'Brien PhD1 ; Alexandra S. Bullough MBChB, FRCA2

Introduction: Emerging data suggests that maternal obstructive sleep apnea may be a risk factor for adverse fetal outcome such as lower birth-weight and reduced Apgar scores. However, the small available literature is conflicting. Given the potential impact of obstructive sleep apnea during pregnancy on fetal outcome, data are urgently required to address this significant public health issue. Therefore, we aimed to determine whether habitual snoring - as a surrogate marker for obstructive sleep apnea - in the last trimester of pregnancy is associated with adverse infant outcome.

Methods: Women carrying a single fetus were recruited during their last trimester of pregnancy and invited to complete several sleep questionnaires. Habitual snoring was defined as snoring ≥3 nights/week and is commonly used for the identification of those at high risk of obstructive sleep apnea. Following delivery, maternal obstetric records were reviewed to determine infant outcomes.

Results: In total, 429 women (mean age 30.15.8 years) have been studied as part of an ongoing investigation. Thirty-five percent reported habitual snoring and 25% were obese (BMI≥30kg/m2). No differences were found in birth-weight between infants born to women with and without habitual snoring (3.290.7kg vs. 3.280.6kg respectively). Similarly, no differences were found in 1 or 5 minute Apgar scores (7.31.9 vs. 7.71.8kg and 8.61.1 vs. 8.71.1 respectively). There was a tendency for the habitual snorers to have 1 and 5 minute Apgar scores ≤7 (34% vs. 25% and 11% vs. 6%) although this did not reach statistical significance (p≤=0.16). In a regression model including habitual snoring, presence of diabetes, maternal age, and race, only gestational age at delivery, and pre-pregnancy BMI were independent predictors of birth-weight (adjusted R2 0.31 p<0.001) and 1-minute Apgar (adjusted R2 0.42, p=0.001). Only gestational age at delivery was predictive of 5-minute Apgar score (adjusted R2 0.31, p=0.002).

Conclusions: Contrary to several reports, our findings do not support the hypothesis that habitual snoring in pregnancy - as a surrogate marker of obstructive sleep apnea - is a predictor of adverse infant outcomes such as lower birth-weight or Apgar scores.

SOAP 2009